HMG-CoA Reductase Inhibitors from Monascus-Fermented Rice

الملخص EN

Seven compounds were isolated from Monascus-fermented rice by column chromatography with silica gel and semiprep HPLC.

Their structures were elucidated by extensive spectroscopic methods.

All compounds displayed HMG-CoA reductase inhibitory potential, among them compound 7 exhibited strong inhibition with IC50 value comparable with lovastatin.

In this study, two compounds (1 and 2) were obtained from natural source for the first time.