Obesity-Related Metabolomic Analysis of Human Subjects in Black Soybean Peptide Intervention Study by Ultraperformance Liquid Chromatography and Quadrupole-Time-of-Flight Mass Spectrometry
المؤلفون المشاركون
Kwon, Dae Young
Kim, Min Jung
Yang, Hye Jeong
Kim, Jin Hee
Lee, Jong Ho
Kim, Kang Sung
Ahn, Chang-Won
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The present study aimed to identify key metabolites related to weight reduction in humans by studying the metabolic profiles of sera obtained from 34 participants who underwent dietary intervention with black soybean peptides (BSP) for 12 weeks.
This research is a sequel to our previous work in which the effects of BSP on BMI and blood composition of lipid were investigated.
Sera of the study were subjected to ultra performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS), and the data were analyzed using partial least-squares discriminate analysis (PLS-DA) score plots.
Body mass index and percent body fat of the test group were reduced.
Levels of betaine, benzoic acid, pyroglutamic acid, pipecolic acid, N-phenylacetamide, uric acid, l-aspartyl-l-phenylalanine, and lysophosphatidyl cholines (lysoPCs) (C18:1, C18:2, C20:1, and C20:4) showed significant increases.
Levels of l-proline, valine, l-leucine/isoleucine, hypoxanthine, glutamine, l-methionine, phenylpyruvic acid, several carnitine derivatives, and lysoPCs (C14:0, PC16:0, C15:0, C16:0, C17:1, C18:0, and C22:0) were significantly decreased.
In particular, lysoPC 16:0 with a VIP value of 12.02 is esteemed to be the most important metabolite for evaluating the differences between the 2 serum samples.
Our result confirmed weight-lowering effects of BSP, accompanied by favorable changes in metabolites in the subjects’ blood.
Therefore, this research enables us to better understand obesity and increases the predictability of the obesity-related risk by studying metabolites present in the blood.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Min Jung& Yang, Hye Jeong& Kim, Jin Hee& Ahn, Chang-Won& Lee, Jong Ho& Kim, Kang Sung…[et al.]. 2013. Obesity-Related Metabolomic Analysis of Human Subjects in Black Soybean Peptide Intervention Study by Ultraperformance Liquid Chromatography and Quadrupole-Time-of-Flight Mass Spectrometry. Journal of Obesity،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-505342
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Min Jung…[et al.]. Obesity-Related Metabolomic Analysis of Human Subjects in Black Soybean Peptide Intervention Study by Ultraperformance Liquid Chromatography and Quadrupole-Time-of-Flight Mass Spectrometry. Journal of Obesity No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-505342
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Min Jung& Yang, Hye Jeong& Kim, Jin Hee& Ahn, Chang-Won& Lee, Jong Ho& Kim, Kang Sung…[et al.]. Obesity-Related Metabolomic Analysis of Human Subjects in Black Soybean Peptide Intervention Study by Ultraperformance Liquid Chromatography and Quadrupole-Time-of-Flight Mass Spectrometry. Journal of Obesity. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-505342
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505342
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر