CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells <200 CellμL : The DART Trial STI Substudy
المؤلفون المشاركون
Munderi, Paula
Gilks, Charles
Grosskurth, Heiner
Mugaba, Susan
Walker, Sarah
Betty, Auma
Kaleebu, Pontiano
Gotch, Frances M.
Serwanga, Jennifer
Pimego, Edward
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
To better understand attributes of ART-associated HIV-induced T-cell responses that might be therapeutically harnessed.
Methods.
CD8+ T-cell responses were evaluated in some HIV-1 chronically infected participants of the fixed duration STI substudy of the DART trial.
Magnitudes, breadths, and functionality of IFN-γ and Perforin responses were compared in STI (n=42) and continuous treatment (CT) (n=46) before and after a single STI cycle when the DART STI trial was stopped early due to inferior clinical outcome in STI participants.
Results.
STI and CT had comparable magnitudes and breadths of monofunctional CD8+IFNγ+ and CD8+Perforin+ responses.
However, STI was associated with significant decline in breadth of bi-functional (CD8+IFNγ+Perforin+) responses; P=.02, Mann-Whitney test.
Conclusions.
STI in individuals initiated onto ART at <200 CD4+ T-cell counts/μl significantly reduced occurrence of bifunctional CD8+IFNγ+/Perforin+ responses.
These data add to others that found no evidence to support STI as a strategy to improve HIV-specific immunity during ART.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Serwanga, Jennifer& Mugaba, Susan& Betty, Auma& Pimego, Edward& Walker, Sarah& Munderi, Paula…[et al.]. 2011. CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells <200 CellμL : The DART Trial STI Substudy. AIDS Research and Treatment،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-505345
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Serwanga, Jennifer…[et al.]. CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells <200 CellμL : The DART Trial STI Substudy. AIDS Research and Treatment No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-505345
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Serwanga, Jennifer& Mugaba, Susan& Betty, Auma& Pimego, Edward& Walker, Sarah& Munderi, Paula…[et al.]. CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells <200 CellμL : The DART Trial STI Substudy. AIDS Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-505345
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505345
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر