CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells <200 CellμL : The DART Trial STI Substudy
Joint Authors
Munderi, Paula
Gilks, Charles
Grosskurth, Heiner
Mugaba, Susan
Walker, Sarah
Betty, Auma
Kaleebu, Pontiano
Gotch, Frances M.
Serwanga, Jennifer
Pimego, Edward
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To better understand attributes of ART-associated HIV-induced T-cell responses that might be therapeutically harnessed.
Methods.
CD8+ T-cell responses were evaluated in some HIV-1 chronically infected participants of the fixed duration STI substudy of the DART trial.
Magnitudes, breadths, and functionality of IFN-γ and Perforin responses were compared in STI (n=42) and continuous treatment (CT) (n=46) before and after a single STI cycle when the DART STI trial was stopped early due to inferior clinical outcome in STI participants.
Results.
STI and CT had comparable magnitudes and breadths of monofunctional CD8+IFNγ+ and CD8+Perforin+ responses.
However, STI was associated with significant decline in breadth of bi-functional (CD8+IFNγ+Perforin+) responses; P=.02, Mann-Whitney test.
Conclusions.
STI in individuals initiated onto ART at <200 CD4+ T-cell counts/μl significantly reduced occurrence of bifunctional CD8+IFNγ+/Perforin+ responses.
These data add to others that found no evidence to support STI as a strategy to improve HIV-specific immunity during ART.
American Psychological Association (APA)
Serwanga, Jennifer& Mugaba, Susan& Betty, Auma& Pimego, Edward& Walker, Sarah& Munderi, Paula…[et al.]. 2011. CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells <200 CellμL : The DART Trial STI Substudy. AIDS Research and Treatment،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-505345
Modern Language Association (MLA)
Serwanga, Jennifer…[et al.]. CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells <200 CellμL : The DART Trial STI Substudy. AIDS Research and Treatment No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-505345
American Medical Association (AMA)
Serwanga, Jennifer& Mugaba, Susan& Betty, Auma& Pimego, Edward& Walker, Sarah& Munderi, Paula…[et al.]. CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells <200 CellμL : The DART Trial STI Substudy. AIDS Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-505345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505345