Determinants of Disability in Multiple Sclerosis : An Immunological and MRI Study
المؤلفون المشاركون
Tavazzi, Eleonora
Rovaris, Marco
Preti, Maria Giulia
Laganà, Maria Marcella
Marventano, Ivana
Cecconi, Pietro
Caputo, Domenico
Piancone, Federica
Baglio, Francesca
Clerici, Mario
Saresella, Marina
Ricci, Cristian
Baselli, Giuseppe
Tortorella, Paola
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Multiple sclerosis (MS) is characterized by a wide interpatient clinical variability and available biomarkers of disease severity still have suboptimal reliability.
We aimed to assess immunological and MRI-derived measures of brain tissue damage in patients with different motor impairment degrees, for in vivo investigating the pathogenesis of MS-related disability.
Twenty-two benign (B), 26 secondary progressive (SP), and 11 early, nondisabled relapsing-remitting (RR) MS patients and 37 healthy controls (HC) underwent conventional and diffusion tensor brain MRI and, as regards MS patients, immunophenotypic and functional analysis of stimulated peripheral blood mononuclear cells (PBMC).
Corticospinal tract (CST) fractional anisotropy and grey matter volume were lower and CST diffusivity was higher in SPMS compared to RRMS and BMS patients.
CD14+IL6+ and CD4+IL25+ cell percentages were higher in BMS than in SPMS patients.
A multivariable model having EDSS as the dependent variable retained the following independent predictors: grey matter volume, CD14+IL6+ and CD4+IL25+ cell percentages.
In patients without motor impairment after long-lasting MS, the grey matter and CST damage degree seem to remain as low as in the earlier disease stages and an immunological pattern suggestive of balanced pro- and anti-inflammatory activity is observed.
MRI-derived and immunological measures might be used as complementary biomarkers of MS severity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tortorella, Paola& Laganà, Maria Marcella& Saresella, Marina& Tavazzi, Eleonora& Preti, Maria Giulia& Ricci, Cristian…[et al.]. 2014. Determinants of Disability in Multiple Sclerosis : An Immunological and MRI Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-505417
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tortorella, Paola…[et al.]. Determinants of Disability in Multiple Sclerosis : An Immunological and MRI Study. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-505417
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tortorella, Paola& Laganà, Maria Marcella& Saresella, Marina& Tavazzi, Eleonora& Preti, Maria Giulia& Ricci, Cristian…[et al.]. Determinants of Disability in Multiple Sclerosis : An Immunological and MRI Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-505417
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505417
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر