Determinants of Disability in Multiple Sclerosis : An Immunological and MRI Study
Joint Authors
Tavazzi, Eleonora
Rovaris, Marco
Preti, Maria Giulia
Laganà, Maria Marcella
Marventano, Ivana
Cecconi, Pietro
Caputo, Domenico
Piancone, Federica
Baglio, Francesca
Clerici, Mario
Saresella, Marina
Ricci, Cristian
Baselli, Giuseppe
Tortorella, Paola
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Multiple sclerosis (MS) is characterized by a wide interpatient clinical variability and available biomarkers of disease severity still have suboptimal reliability.
We aimed to assess immunological and MRI-derived measures of brain tissue damage in patients with different motor impairment degrees, for in vivo investigating the pathogenesis of MS-related disability.
Twenty-two benign (B), 26 secondary progressive (SP), and 11 early, nondisabled relapsing-remitting (RR) MS patients and 37 healthy controls (HC) underwent conventional and diffusion tensor brain MRI and, as regards MS patients, immunophenotypic and functional analysis of stimulated peripheral blood mononuclear cells (PBMC).
Corticospinal tract (CST) fractional anisotropy and grey matter volume were lower and CST diffusivity was higher in SPMS compared to RRMS and BMS patients.
CD14+IL6+ and CD4+IL25+ cell percentages were higher in BMS than in SPMS patients.
A multivariable model having EDSS as the dependent variable retained the following independent predictors: grey matter volume, CD14+IL6+ and CD4+IL25+ cell percentages.
In patients without motor impairment after long-lasting MS, the grey matter and CST damage degree seem to remain as low as in the earlier disease stages and an immunological pattern suggestive of balanced pro- and anti-inflammatory activity is observed.
MRI-derived and immunological measures might be used as complementary biomarkers of MS severity.
American Psychological Association (APA)
Tortorella, Paola& Laganà, Maria Marcella& Saresella, Marina& Tavazzi, Eleonora& Preti, Maria Giulia& Ricci, Cristian…[et al.]. 2014. Determinants of Disability in Multiple Sclerosis : An Immunological and MRI Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-505417
Modern Language Association (MLA)
Tortorella, Paola…[et al.]. Determinants of Disability in Multiple Sclerosis : An Immunological and MRI Study. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-505417
American Medical Association (AMA)
Tortorella, Paola& Laganà, Maria Marcella& Saresella, Marina& Tavazzi, Eleonora& Preti, Maria Giulia& Ricci, Cristian…[et al.]. Determinants of Disability in Multiple Sclerosis : An Immunological and MRI Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-505417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505417