Development and Characterization of In Situ Oral Gel of Spiramycin
المؤلفون المشاركون
Saini, Vinay
Sharma, Jyoti
Sharma, Avinash
Kaur, Rupinder
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The present investigation deals with the optimization, formulation, and characterization of oral in situ gel of spiramycin.
Sodium alginate and hydroxypropyl methylcellulose were used as cross-linking and viscosifying agents, respectively.
Sodium bicarbonate was used as a floating agent.
In preformulation studies, the melting point, pH, and partition coefficient were found to be 133°C, 9.5, and 0.193, respectively.
The drug had retention time at around 2.65 minutes in high performance liquid chromatography (HPLC).
During compatibility studies of drug with all polymers, we observed that there were no changes in the FTIR spectra of a mixture of drug and polymers.
All the formulations showed good pourability.
Floating time and total floating time were ~30 sec and >12 hours, respectively.
During in vitro drug release studies, the drug was released from the formulation around 80–100% for 12–16 hrs.
In TEM analysis, we found that the drug molecules were well entrapped in the polymer and the drug was released slowly for up to 12 hrs.
In these studies, we found that the concentration of sodium alginate and HPMC had significant influence on floating lag time, gelling capacity, and cumulative percentage drug release.
During antimicrobial studies, we found that the formulation containing spiramycin showed good zone of inhibition against different microbial strains (Staphylococcus aureus and Escherichia coli).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sharma, Avinash& Sharma, Jyoti& Kaur, Rupinder& Saini, Vinay. 2014. Development and Characterization of In Situ Oral Gel of Spiramycin. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-505466
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sharma, Avinash…[et al.]. Development and Characterization of In Situ Oral Gel of Spiramycin. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-505466
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sharma, Avinash& Sharma, Jyoti& Kaur, Rupinder& Saini, Vinay. Development and Characterization of In Situ Oral Gel of Spiramycin. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-505466
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505466
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر