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Development and Characterization of In Situ Oral Gel of Spiramycin
Joint Authors
Saini, Vinay
Sharma, Jyoti
Sharma, Avinash
Kaur, Rupinder
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present investigation deals with the optimization, formulation, and characterization of oral in situ gel of spiramycin.
Sodium alginate and hydroxypropyl methylcellulose were used as cross-linking and viscosifying agents, respectively.
Sodium bicarbonate was used as a floating agent.
In preformulation studies, the melting point, pH, and partition coefficient were found to be 133°C, 9.5, and 0.193, respectively.
The drug had retention time at around 2.65 minutes in high performance liquid chromatography (HPLC).
During compatibility studies of drug with all polymers, we observed that there were no changes in the FTIR spectra of a mixture of drug and polymers.
All the formulations showed good pourability.
Floating time and total floating time were ~30 sec and >12 hours, respectively.
During in vitro drug release studies, the drug was released from the formulation around 80–100% for 12–16 hrs.
In TEM analysis, we found that the drug molecules were well entrapped in the polymer and the drug was released slowly for up to 12 hrs.
In these studies, we found that the concentration of sodium alginate and HPMC had significant influence on floating lag time, gelling capacity, and cumulative percentage drug release.
During antimicrobial studies, we found that the formulation containing spiramycin showed good zone of inhibition against different microbial strains (Staphylococcus aureus and Escherichia coli).
American Psychological Association (APA)
Sharma, Avinash& Sharma, Jyoti& Kaur, Rupinder& Saini, Vinay. 2014. Development and Characterization of In Situ Oral Gel of Spiramycin. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-505466
Modern Language Association (MLA)
Sharma, Avinash…[et al.]. Development and Characterization of In Situ Oral Gel of Spiramycin. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-505466
American Medical Association (AMA)
Sharma, Avinash& Sharma, Jyoti& Kaur, Rupinder& Saini, Vinay. Development and Characterization of In Situ Oral Gel of Spiramycin. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-505466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505466