Modulation of c-Fos and BDNF Protein Expression in Pentylenetetrazole-Kindled Mice following the Treatment with Novel Antiepileptic Compound HHL-6
المؤلفون المشاركون
Siddiqui, Bina S.
Jawed, Huma
Ashraf, Nadeem
Malhi, Saima Mahmood
Hanif, Farina
Simjee, Shabana Usman
Kabir, Nurul
Begum, Sabira
Zubair, Farhat
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Brain-derived neurotrophic factor (BDNF) and c-Fos are shown to promote epileptogenesis and are taken as a marker of neuronal activity.
The present study investigated the expression of BDNF and c-Fos in mice brain with pentylenetetrazol- (PTZ-) induced generalized seizure and evaluated the effect of novel tryptamine derivative HHL-6 on the expression of these two markers.
The subconvulsive dose of PTZ (50 mg/kg) was administered on alternate days in the experimental groups until the seizure scores 4-5 developed in the PTZ-control group.
At the end of each experiment, animals were sacrificed, brain samples were collected and cryosectioned, and immunohistochemical analysis of BDNF and c-Fos protein was performed.
Data obtained from two sections per mouse (n=12 animals/group) is presented as means ± S.E.M.
The test compound HHL-6 demonstrated a potent anticonvulsant activity in the PTZ-induced seizure in mice.
Significant reduction in the BDNF (P<0.003) and c-Fos (P<0.01) protein expression was observed in the HHL-6 treated group.
Based on these results we suggest that one of the possible mechanisms of HHL-6 to inhibit epileptogenesis might be due to its controlling effect on the cellular and molecular expression of the factors that contribute to the development of epileptogenic plasticity in the CNS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Malhi, Saima Mahmood& Jawed, Huma& Hanif, Farina& Ashraf, Nadeem& Zubair, Farhat& Siddiqui, Bina S.…[et al.]. 2014. Modulation of c-Fos and BDNF Protein Expression in Pentylenetetrazole-Kindled Mice following the Treatment with Novel Antiepileptic Compound HHL-6. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-505511
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Malhi, Saima Mahmood…[et al.]. Modulation of c-Fos and BDNF Protein Expression in Pentylenetetrazole-Kindled Mice following the Treatment with Novel Antiepileptic Compound HHL-6. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-505511
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Malhi, Saima Mahmood& Jawed, Huma& Hanif, Farina& Ashraf, Nadeem& Zubair, Farhat& Siddiqui, Bina S.…[et al.]. Modulation of c-Fos and BDNF Protein Expression in Pentylenetetrazole-Kindled Mice following the Treatment with Novel Antiepileptic Compound HHL-6. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-505511
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505511
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر