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Hair-Normalized Cortisol Waking Response as a Novel Biomarker of Hypothalamic-Pituitary-Adrenal Axis Activity following Acute Trauma : A Proof-of-Concept Study with Pilot Results
المؤلفون المشاركون
Koren, Gideon
Walton, David M.
Van Uum, Stanislaus H. M.
MacDermid, Joy C.
Russell, Evan
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The mechanisms underlying the development of persistent posttraumatic pain and disability remain elusive.
Recent evidence suggests that disordered stress-system pathway (hypothalamic-pituitary-adrenal axis) activity may be responsible for the genesis and maintenance of long-term sensory and emotional problems.
However, confidence in current evidence is limited by the necessarily retrospective collection of data.
Hair cortisol can serve as a calendar of HPA axis activity going back several months prior to injury.
The purposes of this pilot study were to determine the feasibility of using hair cortisol and hair-normalized salivary cortisol as biomarkers of distress following traumatic injuries of whiplash or distal radius fracture.
Ten subjects provided complete data within 3 weeks of injury.
Hair cortisol, cortisol waking response (CWR), and mean daily cortisol (MDC) were captured at inception, as were self-report indicators of pain, disability, and pain catastrophizing.
Pain and disability were also captured 3 months after injury.
Results indicate that cortisol waking response may be a useful biomarker of current distress as measured using the pain catastrophizing scale, especially when normalized to 3-month hair cortisol (r=0.77 raw, 0.93 normalized).
Hair-normalized CWR may also have predictive capacity, correlating with 3-month self-reported disability at r=0.70.
While promising, the results must be viewed in light of the small sample.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Walton, David M.& MacDermid, Joy C.& Russell, Evan& Koren, Gideon& Van Uum, Stanislaus H. M.. 2013. Hair-Normalized Cortisol Waking Response as a Novel Biomarker of Hypothalamic-Pituitary-Adrenal Axis Activity following Acute Trauma : A Proof-of-Concept Study with Pilot Results. Pain Research and Treatment،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-505522
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Walton, David M.…[et al.]. Hair-Normalized Cortisol Waking Response as a Novel Biomarker of Hypothalamic-Pituitary-Adrenal Axis Activity following Acute Trauma : A Proof-of-Concept Study with Pilot Results. Pain Research and Treatment No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-505522
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Walton, David M.& MacDermid, Joy C.& Russell, Evan& Koren, Gideon& Van Uum, Stanislaus H. M.. Hair-Normalized Cortisol Waking Response as a Novel Biomarker of Hypothalamic-Pituitary-Adrenal Axis Activity following Acute Trauma : A Proof-of-Concept Study with Pilot Results. Pain Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-505522
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505522
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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