Hair-Normalized Cortisol Waking Response as a Novel Biomarker of Hypothalamic-Pituitary-Adrenal Axis Activity following Acute Trauma : A Proof-of-Concept Study with Pilot Results
Joint Authors
Koren, Gideon
Walton, David M.
Van Uum, Stanislaus H. M.
MacDermid, Joy C.
Russell, Evan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The mechanisms underlying the development of persistent posttraumatic pain and disability remain elusive.
Recent evidence suggests that disordered stress-system pathway (hypothalamic-pituitary-adrenal axis) activity may be responsible for the genesis and maintenance of long-term sensory and emotional problems.
However, confidence in current evidence is limited by the necessarily retrospective collection of data.
Hair cortisol can serve as a calendar of HPA axis activity going back several months prior to injury.
The purposes of this pilot study were to determine the feasibility of using hair cortisol and hair-normalized salivary cortisol as biomarkers of distress following traumatic injuries of whiplash or distal radius fracture.
Ten subjects provided complete data within 3 weeks of injury.
Hair cortisol, cortisol waking response (CWR), and mean daily cortisol (MDC) were captured at inception, as were self-report indicators of pain, disability, and pain catastrophizing.
Pain and disability were also captured 3 months after injury.
Results indicate that cortisol waking response may be a useful biomarker of current distress as measured using the pain catastrophizing scale, especially when normalized to 3-month hair cortisol (r=0.77 raw, 0.93 normalized).
Hair-normalized CWR may also have predictive capacity, correlating with 3-month self-reported disability at r=0.70.
While promising, the results must be viewed in light of the small sample.
American Psychological Association (APA)
Walton, David M.& MacDermid, Joy C.& Russell, Evan& Koren, Gideon& Van Uum, Stanislaus H. M.. 2013. Hair-Normalized Cortisol Waking Response as a Novel Biomarker of Hypothalamic-Pituitary-Adrenal Axis Activity following Acute Trauma : A Proof-of-Concept Study with Pilot Results. Pain Research and Treatment،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-505522
Modern Language Association (MLA)
Walton, David M.…[et al.]. Hair-Normalized Cortisol Waking Response as a Novel Biomarker of Hypothalamic-Pituitary-Adrenal Axis Activity following Acute Trauma : A Proof-of-Concept Study with Pilot Results. Pain Research and Treatment No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-505522
American Medical Association (AMA)
Walton, David M.& MacDermid, Joy C.& Russell, Evan& Koren, Gideon& Van Uum, Stanislaus H. M.. Hair-Normalized Cortisol Waking Response as a Novel Biomarker of Hypothalamic-Pituitary-Adrenal Axis Activity following Acute Trauma : A Proof-of-Concept Study with Pilot Results. Pain Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-505522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505522