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Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse
المؤلفون المشاركون
Lee, Hyung-chul
Uugangerel, Tserendorj
Kang, Byeong-Cheol
Kim, Jong Min
Yang, Solmon
Jang, In-ki
Kim, Chong Soo
Lee, Kook-Hyun
المصدر
Anesthesiology Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-11
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Bupivacaine inhibits cardiac conduction and contractility.
Insulin enhances cardiac repolarization and myocardial contractility.
We hypothesizes that insulin therapy would be effective in resuscitating bupivacaine-induced cardiac toxicity in rabbits.
Twelve rabbits were tracheally intubated and midline sternotomy was performed under general anesthesia.
Cardiovascular collapse (CVC) was induced by an IV bolus injection of bupivacaine 10 mg/kg.
The rabbits were treated with either saline (control) or insulin injection, administered as a 2 U/kg bolus.
Internal cardiac massage was performed until the return of spontaneous circulation (ROSC) and the time to the return of sinus rhythm (ROSR) was also noted in both groups.
Arterial blood pressure, and electrocardiography were continuously monitored for 30 min and plasma bupivacaine concentrations at every 5 min.
The ROSC, ROSR and normalization of QRS duration were attained faster in the insulin-treated group than in the control group.
At the ROSC, there was a significant difference in bupivacaine concentration between two groups.
Insulin facilitates the return of myocardial contractility and conduction from bupivacaine-induced CVC in rabbits.
However, recovery of cardiac conduction is dependent mainly on the change of plasma bupivacaine concentrations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Solmon& Uugangerel, Tserendorj& Jang, In-ki& Lee, Hyung-chul& Kim, Jong Min& Kang, Byeong-Cheol…[et al.]. 2012. Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse. Anesthesiology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-505593
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Solmon…[et al.]. Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse. Anesthesiology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-505593
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Solmon& Uugangerel, Tserendorj& Jang, In-ki& Lee, Hyung-chul& Kim, Jong Min& Kang, Byeong-Cheol…[et al.]. Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse. Anesthesiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-505593
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505593
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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