![](/images/graphics-bg.png)
Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse
Joint Authors
Lee, Hyung-chul
Uugangerel, Tserendorj
Kang, Byeong-Cheol
Kim, Jong Min
Yang, Solmon
Jang, In-ki
Kim, Chong Soo
Lee, Kook-Hyun
Source
Anesthesiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Bupivacaine inhibits cardiac conduction and contractility.
Insulin enhances cardiac repolarization and myocardial contractility.
We hypothesizes that insulin therapy would be effective in resuscitating bupivacaine-induced cardiac toxicity in rabbits.
Twelve rabbits were tracheally intubated and midline sternotomy was performed under general anesthesia.
Cardiovascular collapse (CVC) was induced by an IV bolus injection of bupivacaine 10 mg/kg.
The rabbits were treated with either saline (control) or insulin injection, administered as a 2 U/kg bolus.
Internal cardiac massage was performed until the return of spontaneous circulation (ROSC) and the time to the return of sinus rhythm (ROSR) was also noted in both groups.
Arterial blood pressure, and electrocardiography were continuously monitored for 30 min and plasma bupivacaine concentrations at every 5 min.
The ROSC, ROSR and normalization of QRS duration were attained faster in the insulin-treated group than in the control group.
At the ROSC, there was a significant difference in bupivacaine concentration between two groups.
Insulin facilitates the return of myocardial contractility and conduction from bupivacaine-induced CVC in rabbits.
However, recovery of cardiac conduction is dependent mainly on the change of plasma bupivacaine concentrations.
American Psychological Association (APA)
Yang, Solmon& Uugangerel, Tserendorj& Jang, In-ki& Lee, Hyung-chul& Kim, Jong Min& Kang, Byeong-Cheol…[et al.]. 2012. Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse. Anesthesiology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-505593
Modern Language Association (MLA)
Yang, Solmon…[et al.]. Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse. Anesthesiology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-505593
American Medical Association (AMA)
Yang, Solmon& Uugangerel, Tserendorj& Jang, In-ki& Lee, Hyung-chul& Kim, Jong Min& Kang, Byeong-Cheol…[et al.]. Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse. Anesthesiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-505593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505593