Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy

المؤلفون المشاركون

Uzu, Takashi
Kume, Shinji
Koya, Daisuke
Isshiki, Keiji

المصدر

PPAR Research

العدد

المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2009-03-04

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

Diabetic nephropathy is a leading cause of end-stage renal disease, which is increasing in incidence worldwide, despite intensive treatment approaches such as glycemic and blood pressure control in patients with diabetes mellitus.

New therapeutic strategies are needed to prevent the onset of diabetic nephropathy.

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostases.

These agents might prevent the progression of diabetic nephropathy, since PPAR agonists improve dyslipidemia and insulin resistance.

Furthermore, data from murine models suggest that PPAR agonists also have independent renoprotective effects by suppressing inflammation, oxidative stress, lipotoxicity, and activation of the renin-angiotensin system.

This review summarizes data from clinical and experimental studies regarding the relationship between PPARs and diabetic nephropathy.

The therapeutic potential of PPAR agonists in the treatment of diabetic nephropathy is also discussed.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kume, Shinji& Uzu, Takashi& Isshiki, Keiji& Koya, Daisuke. 2009. Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy. PPAR Research،Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-505652

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kume, Shinji…[et al.]. Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy. PPAR Research No. 2008 (2008), pp.1-11.
https://search.emarefa.net/detail/BIM-505652

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kume, Shinji& Uzu, Takashi& Isshiki, Keiji& Koya, Daisuke. Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy. PPAR Research. 2009. Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-505652

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-505652