Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy
Joint Authors
Uzu, Takashi
Kume, Shinji
Koya, Daisuke
Isshiki, Keiji
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Diabetic nephropathy is a leading cause of end-stage renal disease, which is increasing in incidence worldwide, despite intensive treatment approaches such as glycemic and blood pressure control in patients with diabetes mellitus.
New therapeutic strategies are needed to prevent the onset of diabetic nephropathy.
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostases.
These agents might prevent the progression of diabetic nephropathy, since PPAR agonists improve dyslipidemia and insulin resistance.
Furthermore, data from murine models suggest that PPAR agonists also have independent renoprotective effects by suppressing inflammation, oxidative stress, lipotoxicity, and activation of the renin-angiotensin system.
This review summarizes data from clinical and experimental studies regarding the relationship between PPARs and diabetic nephropathy.
The therapeutic potential of PPAR agonists in the treatment of diabetic nephropathy is also discussed.
American Psychological Association (APA)
Kume, Shinji& Uzu, Takashi& Isshiki, Keiji& Koya, Daisuke. 2009. Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy. PPAR Research،Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-505652
Modern Language Association (MLA)
Kume, Shinji…[et al.]. Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy. PPAR Research No. 2008 (2008), pp.1-11.
https://search.emarefa.net/detail/BIM-505652
American Medical Association (AMA)
Kume, Shinji& Uzu, Takashi& Isshiki, Keiji& Koya, Daisuke. Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy. PPAR Research. 2009. Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-505652
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505652