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Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPARγ Signaling and Inflammation in Murine Mammary Tissue
المؤلفون المشاركون
Teter, Beverly B.
Rodriguez-Zas, Sandra L.
Erdman, Richard A.
Loor, Juan J.
Khan, Muhammad J.
Kadegowda, Anil K. G.
Piperova, Liliana S.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-14
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Exogenous trans-10, cis-12-CLA (CLA) reduces lipid synthesis in murine adipose and mammary (MG) tissues.
However, genomewide alterations in MG and liver (LIV) associated with dietary CLA during lactation remain unknown.
We fed mice (n=5/diet) control or control + trans-10, cis-12-CLA (37 mg/day) between d 6 and d 10 postpartum.
The 35,302 annotated murine exonic evidence-based oligo (MEEBO) microarray and quantitative RT-PCR were used for transcript profiling.
Milk fat concentration was 44% lower on d 10 versus d 6 due to CLA.
The CLA diet resulted in differential expression of 1,496 genes.
Bioinformatics analyses underscored that a major effect of CLA on MG encompassed alterations in cellular signaling pathways and phospholipid species biosynthesis.
Dietary CLA induced genes related to ER stress (Xbp1), apoptosis (Bcl2), and inflammation (Orm1, Saa2, and Cp).
It also induced marked inhibition of PPARγ signaling, including downregulation of Pparg and Srebf1 and several lipogenic target genes (Scd, Fasn, and Gpam).
In LIV, CLA induced hepatic steatosis probably through perturbations in the mitochondrial functions and induction of ER stress.
Overall, results from this study underscored the role of PPARγ signaling on mammary lipogenic target regulation.
The proinflammatory effect due to CLA could be related to inhibition of PPARγ signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kadegowda, Anil K. G.& Khan, Muhammad J.& Piperova, Liliana S.& Teter, Beverly B.& Rodriguez-Zas, Sandra L.& Erdman, Richard A.…[et al.]. 2013. Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPARγ Signaling and Inflammation in Murine Mammary Tissue. Journal of Lipids،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-505714
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kadegowda, Anil K. G.…[et al.]. Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPARγ Signaling and Inflammation in Murine Mammary Tissue. Journal of Lipids No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-505714
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kadegowda, Anil K. G.& Khan, Muhammad J.& Piperova, Liliana S.& Teter, Beverly B.& Rodriguez-Zas, Sandra L.& Erdman, Richard A.…[et al.]. Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPARγ Signaling and Inflammation in Murine Mammary Tissue. Journal of Lipids. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-505714
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505714
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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