![](/images/graphics-bg.png)
Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPARγ Signaling and Inflammation in Murine Mammary Tissue
Joint Authors
Teter, Beverly B.
Rodriguez-Zas, Sandra L.
Erdman, Richard A.
Loor, Juan J.
Khan, Muhammad J.
Kadegowda, Anil K. G.
Piperova, Liliana S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-14
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Exogenous trans-10, cis-12-CLA (CLA) reduces lipid synthesis in murine adipose and mammary (MG) tissues.
However, genomewide alterations in MG and liver (LIV) associated with dietary CLA during lactation remain unknown.
We fed mice (n=5/diet) control or control + trans-10, cis-12-CLA (37 mg/day) between d 6 and d 10 postpartum.
The 35,302 annotated murine exonic evidence-based oligo (MEEBO) microarray and quantitative RT-PCR were used for transcript profiling.
Milk fat concentration was 44% lower on d 10 versus d 6 due to CLA.
The CLA diet resulted in differential expression of 1,496 genes.
Bioinformatics analyses underscored that a major effect of CLA on MG encompassed alterations in cellular signaling pathways and phospholipid species biosynthesis.
Dietary CLA induced genes related to ER stress (Xbp1), apoptosis (Bcl2), and inflammation (Orm1, Saa2, and Cp).
It also induced marked inhibition of PPARγ signaling, including downregulation of Pparg and Srebf1 and several lipogenic target genes (Scd, Fasn, and Gpam).
In LIV, CLA induced hepatic steatosis probably through perturbations in the mitochondrial functions and induction of ER stress.
Overall, results from this study underscored the role of PPARγ signaling on mammary lipogenic target regulation.
The proinflammatory effect due to CLA could be related to inhibition of PPARγ signaling.
American Psychological Association (APA)
Kadegowda, Anil K. G.& Khan, Muhammad J.& Piperova, Liliana S.& Teter, Beverly B.& Rodriguez-Zas, Sandra L.& Erdman, Richard A.…[et al.]. 2013. Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPARγ Signaling and Inflammation in Murine Mammary Tissue. Journal of Lipids،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-505714
Modern Language Association (MLA)
Kadegowda, Anil K. G.…[et al.]. Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPARγ Signaling and Inflammation in Murine Mammary Tissue. Journal of Lipids No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-505714
American Medical Association (AMA)
Kadegowda, Anil K. G.& Khan, Muhammad J.& Piperova, Liliana S.& Teter, Beverly B.& Rodriguez-Zas, Sandra L.& Erdman, Richard A.…[et al.]. Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPARγ Signaling and Inflammation in Murine Mammary Tissue. Journal of Lipids. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-505714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505714