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New Insights in Recurrent HCV Infection after Liver Transplantation
المؤلفون المشاركون
Wang, Shen-Nien
Yeh, Ming-Lun
Hsu, Shih-Hsien
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Hepatitis C virus (HCV) is a small-enveloped RNA virus belonging to the Flaviviridae family.
Since first identified in 1989, HCV has been estimated to infect 170 million people worldwide.
Mostly chronic hepatitis C virus has a uniform natural history, from liver cirrhosis to the development of hepatocellular carcinoma.
The current therapy for HCV infection consists of a combination of Pegylated interferon and ribavirin.
On the other hand, HCV-related liver disease is also the leading indication for liver transplantation.
However, posttransplant HCV re-infection of the graft has been reported to be universal.
Furthermore, the graft after HCV re-infection often results in accelerated progression to liver failure.
In addition, treatment of recurrent HCV infection after liver transplantation is often compromised by enhanced adverse effects and limited efficacy of interferon-based therapies.
Taken together, poor outcome after HCV re-infection, regardless of grafts or recipients, poses a major issue for the hepatologists and transplant surgeons.
The aim of this paper is to review several specific aspects regarding HCV re-infection after transplant: risk factors, current therapeutics for HCV in different stages of liver transplantation, cellular function of HCV proteins, and molecular mechanisms of HCV entry.
Hopefully, this paper will inspire new strategies and novel inhibitors against recurrent HCV infection after liver transplantation and greatly improve its overall outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hsu, Shih-Hsien& Yeh, Ming-Lun& Wang, Shen-Nien. 2013. New Insights in Recurrent HCV Infection after Liver Transplantation. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-505732
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hsu, Shih-Hsien…[et al.]. New Insights in Recurrent HCV Infection after Liver Transplantation. Clinical and Developmental Immunology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-505732
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hsu, Shih-Hsien& Yeh, Ming-Lun& Wang, Shen-Nien. New Insights in Recurrent HCV Infection after Liver Transplantation. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-505732
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505732
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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