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New Insights in Recurrent HCV Infection after Liver Transplantation
Joint Authors
Wang, Shen-Nien
Yeh, Ming-Lun
Hsu, Shih-Hsien
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hepatitis C virus (HCV) is a small-enveloped RNA virus belonging to the Flaviviridae family.
Since first identified in 1989, HCV has been estimated to infect 170 million people worldwide.
Mostly chronic hepatitis C virus has a uniform natural history, from liver cirrhosis to the development of hepatocellular carcinoma.
The current therapy for HCV infection consists of a combination of Pegylated interferon and ribavirin.
On the other hand, HCV-related liver disease is also the leading indication for liver transplantation.
However, posttransplant HCV re-infection of the graft has been reported to be universal.
Furthermore, the graft after HCV re-infection often results in accelerated progression to liver failure.
In addition, treatment of recurrent HCV infection after liver transplantation is often compromised by enhanced adverse effects and limited efficacy of interferon-based therapies.
Taken together, poor outcome after HCV re-infection, regardless of grafts or recipients, poses a major issue for the hepatologists and transplant surgeons.
The aim of this paper is to review several specific aspects regarding HCV re-infection after transplant: risk factors, current therapeutics for HCV in different stages of liver transplantation, cellular function of HCV proteins, and molecular mechanisms of HCV entry.
Hopefully, this paper will inspire new strategies and novel inhibitors against recurrent HCV infection after liver transplantation and greatly improve its overall outcome.
American Psychological Association (APA)
Hsu, Shih-Hsien& Yeh, Ming-Lun& Wang, Shen-Nien. 2013. New Insights in Recurrent HCV Infection after Liver Transplantation. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-505732
Modern Language Association (MLA)
Hsu, Shih-Hsien…[et al.]. New Insights in Recurrent HCV Infection after Liver Transplantation. Clinical and Developmental Immunology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-505732
American Medical Association (AMA)
Hsu, Shih-Hsien& Yeh, Ming-Lun& Wang, Shen-Nien. New Insights in Recurrent HCV Infection after Liver Transplantation. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-505732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505732