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A Randomized Multicenter Study Comparing a Tacrolimus-Based Protocol with and without Steroids in HCV-Positive Liver Allograft Recipients
المؤلفون المشاركون
Gugenheim, Jean
Trunečka, Pavel
Neumann, Ulf P.
Gerunda, Giorgio Enrico
Samuel, Didier
Friman, Styrbjörn
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Allograft reinfection with hepatitis C virus (HCV) occurs universally in liver transplant recipients.
Corticosteroids can contribute to HCV recurrence.
This randomized study evaluated HCV recurrence in HCV-positive liver allograft recipients using steroid-free immunosuppression.
All patients received tacrolimus (TAC) at an initial dose of 0.10–0.15 mg/kg.
The steroid-free arm (TAC/daclizumab (TAC/DAC, n=67)) received daclizumab induction, and the steroid arm (TAC/steroid (TAC/STR, n=68)) received a steroid bolus (≤ 500mg) followed by 15–20 mg/day with discontinuation after month 3.
Median HCV viral load at month 12, the primary endpoint, was similar at 5.46 (0.95–6.54) IU/mL with TAC/DAC and 5.91 (0.95–6.89) IU/mL with TAC/STR.
Small numerical differences in the estimated rate of freedom from HCV recurrence (19.1 versus 13.8%) and freedom from biopsy proven rejection (78.4 versus 66.1%) were observed between TAC/DAC and TAC/STR.
Patient survival estimates were significantly lower with TAC/DAC than with TAC/STR (83.1 versus 95.5%; 95% CI, −0.227 to −0.019%), and graft survival was numerically lower (80.1 versus 91.1%, P=NS).
Completion rates (45 versus 82%) indicated poorer tolerability with TAC/DAC than with TAC/STR.
Steroid-free immunosuppression had no real impact on HCV viral load.
HCV recurrence was higher with TAC/STR.
Results are inconclusive due to the unexpected lower completion rates in the TAC/DAC arm.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Neumann, Ulf P.& Samuel, Didier& Trunečka, Pavel& Gugenheim, Jean& Gerunda, Giorgio Enrico& Friman, Styrbjörn. 2012. A Randomized Multicenter Study Comparing a Tacrolimus-Based Protocol with and without Steroids in HCV-Positive Liver Allograft Recipients. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-506092
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Neumann, Ulf P.…[et al.]. A Randomized Multicenter Study Comparing a Tacrolimus-Based Protocol with and without Steroids in HCV-Positive Liver Allograft Recipients. Journal of Transplantation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-506092
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Neumann, Ulf P.& Samuel, Didier& Trunečka, Pavel& Gugenheim, Jean& Gerunda, Giorgio Enrico& Friman, Styrbjörn. A Randomized Multicenter Study Comparing a Tacrolimus-Based Protocol with and without Steroids in HCV-Positive Liver Allograft Recipients. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-506092
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506092
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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