Protective Effect of Alpha-Tocopherol Isomer from Vitamin E against the H2O2 Induced Toxicity on Dental Pulp Cells
المؤلفون المشاركون
De Souza Costa, Carlos Alberto
Vargas, Fernanda da Silveira
Hebling, Josimeri
Soares, Diana Gabriela
Ribeiro, Ana Paula Dias
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-21
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The aim of this study was to evaluate the protective effects of different concentrations of vitamin E alpha-tocopherol (α-T) isomer against the toxicity of hydrogen peroxide (H2O2) on dental pulp cells.
The cells (MDPC-23) were seeded in 96-well plates for 72 hours, followed by treatment with 1, 3, 5, or 10 mM α-T for 60 minutes.
They were then exposed or not to H2O2 for 30 minutes.
In positive and negative control groups, the cells were exposed to culture medium with or without H2O2 (0.018%), respectively.
Cell viability was evaluated by MTT assay (Kruskal-Wallis and Mann-Whitney tests; α=5%).
Significant reduction of cell viability (58.5%) was observed in positive control compared with the negative control.
Cells pretreated with α-T at 1, 3, 5, and 10 mM concentrations and exposed to H2O2 had their viability decreased by 43%, 32%, 25%, and 27.5%, respectively.
These values were significantly lower than those observed in the positive control, thereby showing a protective effect of α-T against the H2O2 toxicity.
Overall, the vitamin E α-T isomer protected the immortalized MDPC-23 pulp cells against the toxic effects of H2O2.
The most effective cell protection was provided by 5 and 10 mM concentrations of α-T.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vargas, Fernanda da Silveira& Soares, Diana Gabriela& Ribeiro, Ana Paula Dias& Hebling, Josimeri& De Souza Costa, Carlos Alberto. 2014. Protective Effect of Alpha-Tocopherol Isomer from Vitamin E against the H2O2 Induced Toxicity on Dental Pulp Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-506162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vargas, Fernanda da Silveira…[et al.]. Protective Effect of Alpha-Tocopherol Isomer from Vitamin E against the H2O2 Induced Toxicity on Dental Pulp Cells. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-506162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vargas, Fernanda da Silveira& Soares, Diana Gabriela& Ribeiro, Ana Paula Dias& Hebling, Josimeri& De Souza Costa, Carlos Alberto. Protective Effect of Alpha-Tocopherol Isomer from Vitamin E against the H2O2 Induced Toxicity on Dental Pulp Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-506162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر