Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice
المؤلفون المشاركون
Sheu, Ming-Jyh
Huang, Shyh-Shyun
Lin, Ying-Chih
Huang, Guan-Jhong
Chiu, Chuan-Sung
Shie, Pei-Hsin
Chen, Hsien-Jung
Hou, Wen-Chi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Asiatic acid (AA), a pentacyclic triterpene compound in the medicinal plant Centella asiatica, was evaluated for antinociceptive and anti-inflammatory effects.
Treatment of male ICR mice with AA significantly inhibited the numbers of acetic acid-induced writhing responses and the formalin-induced pain in the late phase.
In the anti-inflammatory test, AA decreased the paw edema at the 4th and 5th h after λ-carrageenan (Carr) administration and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the liver tissue.
AA decreased the nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) levels on serum level at the 5th h after Carr injection.
Western blotting revealed that AA decreased Carr-induced inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), and nuclear factor-κB (NF-κB) expressions at the 5th h in the edema paw.
An intraperitoneal (i.p.) injection treatment with AA also diminished neutrophil infiltration into sites of inflammation as did indomethacin (Indo).
The anti-inflammatory mechanisms of AA might be related to the decrease in the level of MDA, iNOS, COX-2, and NF-κB in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Shyh-Shyun& Chiu, Chuan-Sung& Chen, Hsien-Jung& Hou, Wen-Chi& Sheu, Ming-Jyh& Lin, Ying-Chih…[et al.]. 2011. Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506219
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Shyh-Shyun…[et al.]. Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-506219
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Shyh-Shyun& Chiu, Chuan-Sung& Chen, Hsien-Jung& Hou, Wen-Chi& Sheu, Ming-Jyh& Lin, Ying-Chih…[et al.]. Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506219
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506219
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر