Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice
Joint Authors
Sheu, Ming-Jyh
Huang, Shyh-Shyun
Lin, Ying-Chih
Huang, Guan-Jhong
Chiu, Chuan-Sung
Shie, Pei-Hsin
Chen, Hsien-Jung
Hou, Wen-Chi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Asiatic acid (AA), a pentacyclic triterpene compound in the medicinal plant Centella asiatica, was evaluated for antinociceptive and anti-inflammatory effects.
Treatment of male ICR mice with AA significantly inhibited the numbers of acetic acid-induced writhing responses and the formalin-induced pain in the late phase.
In the anti-inflammatory test, AA decreased the paw edema at the 4th and 5th h after λ-carrageenan (Carr) administration and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the liver tissue.
AA decreased the nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) levels on serum level at the 5th h after Carr injection.
Western blotting revealed that AA decreased Carr-induced inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), and nuclear factor-κB (NF-κB) expressions at the 5th h in the edema paw.
An intraperitoneal (i.p.) injection treatment with AA also diminished neutrophil infiltration into sites of inflammation as did indomethacin (Indo).
The anti-inflammatory mechanisms of AA might be related to the decrease in the level of MDA, iNOS, COX-2, and NF-κB in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver.
American Psychological Association (APA)
Huang, Shyh-Shyun& Chiu, Chuan-Sung& Chen, Hsien-Jung& Hou, Wen-Chi& Sheu, Ming-Jyh& Lin, Ying-Chih…[et al.]. 2011. Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506219
Modern Language Association (MLA)
Huang, Shyh-Shyun…[et al.]. Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-506219
American Medical Association (AMA)
Huang, Shyh-Shyun& Chiu, Chuan-Sung& Chen, Hsien-Jung& Hou, Wen-Chi& Sheu, Ming-Jyh& Lin, Ying-Chih…[et al.]. Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506219