Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B

المؤلفون المشاركون

Naderi, Elnaz
Poustchi, Hossein
Sotoudeh, Masoud
Katoonizadeh, Aezam
Mohamadkhani, Ashraf
Montazeri, Ghodratollah

المصدر

International Journal of Inflammation

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-01-21

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Humoral immunity constitutes major defense mechanism against viral infections.

However, the association of hepatic injury and B-cells population in chronic hepatitis B virus (HBV) carriers has not been studied well.

In this study, fifty seven hepatitis B surface antigen (HBsAg) positive and HBeAg negative patients were studied to determine the expression of CD20, a cell surface marker expressed on B-cells, in liver biopsy sections using immunohistochemistry.

The patients’ clinical data at the time of liver biopsy were acquired from their medical records.

There was a significant association between log HBV DNA and both ALT (r=0.36, P=0.006) and histologic activity index (HAI) total score (r=0.3, P=0.02), respectively.

The CD20 was expressed in all 57 liver biopsy samples with a submembranous and membranous staining pattern and its expression was significantly associated with HAI total score (r=0.32, P=0.01) and stage of fibrosis (r=0.31, P=0.02).

The susceptible B lymphocytes to hepatitis B virus might be implicated in the development of immune mediated inflammation of HBV-induced hepatic injury.

The present data also support that the liver is potentially one of the secondary lymphoid organs.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Mohamadkhani, Ashraf& Naderi, Elnaz& Sotoudeh, Masoud& Katoonizadeh, Aezam& Montazeri, Ghodratollah& Poustchi, Hossein. 2014. Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-506317

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Mohamadkhani, Ashraf…[et al.]. Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B. International Journal of Inflammation No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-506317

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Mohamadkhani, Ashraf& Naderi, Elnaz& Sotoudeh, Masoud& Katoonizadeh, Aezam& Montazeri, Ghodratollah& Poustchi, Hossein. Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-506317

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-506317