Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B
Joint Authors
Naderi, Elnaz
Poustchi, Hossein
Sotoudeh, Masoud
Katoonizadeh, Aezam
Mohamadkhani, Ashraf
Montazeri, Ghodratollah
Source
International Journal of Inflammation
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Humoral immunity constitutes major defense mechanism against viral infections.
However, the association of hepatic injury and B-cells population in chronic hepatitis B virus (HBV) carriers has not been studied well.
In this study, fifty seven hepatitis B surface antigen (HBsAg) positive and HBeAg negative patients were studied to determine the expression of CD20, a cell surface marker expressed on B-cells, in liver biopsy sections using immunohistochemistry.
The patients’ clinical data at the time of liver biopsy were acquired from their medical records.
There was a significant association between log HBV DNA and both ALT (r=0.36, P=0.006) and histologic activity index (HAI) total score (r=0.3, P=0.02), respectively.
The CD20 was expressed in all 57 liver biopsy samples with a submembranous and membranous staining pattern and its expression was significantly associated with HAI total score (r=0.32, P=0.01) and stage of fibrosis (r=0.31, P=0.02).
The susceptible B lymphocytes to hepatitis B virus might be implicated in the development of immune mediated inflammation of HBV-induced hepatic injury.
The present data also support that the liver is potentially one of the secondary lymphoid organs.
American Psychological Association (APA)
Mohamadkhani, Ashraf& Naderi, Elnaz& Sotoudeh, Masoud& Katoonizadeh, Aezam& Montazeri, Ghodratollah& Poustchi, Hossein. 2014. Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-506317
Modern Language Association (MLA)
Mohamadkhani, Ashraf…[et al.]. Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B. International Journal of Inflammation No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-506317
American Medical Association (AMA)
Mohamadkhani, Ashraf& Naderi, Elnaz& Sotoudeh, Masoud& Katoonizadeh, Aezam& Montazeri, Ghodratollah& Poustchi, Hossein. Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-506317
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506317