![](/images/graphics-bg.png)
EGFR Monoclonal Antibodies in the Treatment of Squamous Cell Carcinoma of the Head and Neck : A View beyond Cetuximab
المؤلفون المشاركون
Saba, Nabil F.
Kono, Scott A.
Haigentz, Missak
Yom, Sue S.
المصدر
Chemotherapy Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Squamous cell carcinoma of the head and neck (SCCHN) is a prevalent disease both in the United States and worldwide with an overall poor prognosis, in part due to limited activity of existing therapy.
Primary therapy is largely dictated by the anatomical origin of the cancer and whether distant disease is present.
Many patients with localized disease are treated with chemoradiotherapy, either in the definitive or adjuvant setting, and those with metastatic disease are treated with palliative chemotherapy.
The chemotherapy used in SCCHN can be toxic, whether given with radiation or alone.
The epidermal growth factor receptor (EGFR) is highly expressed in SCCHN and serves as a logical therapeutic target.
EGFR-directed monoclonal antibodies (MoAbs) have higher activity in SCCHN than small molecule tyrosine kinase inhibitors.
Cetuximab, a widely studied EGFR MoAb, is FDA approved in the metastatic setting, as well as with radiation for locally advanced disease.
Despite improvements in survival when cetuximab is incorporated with chemotherapy for metastatic disease, the prognosis of patients remains poor.
Novel EGFR MoAbs are being developed with the goal of improving efficacy and tolerability.
This paper will summarize the use of EGFR-directed MoAbs in treating SCCHN with a focus on novel agents being tested.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kono, Scott A.& Haigentz, Missak& Yom, Sue S.& Saba, Nabil F.. 2012. EGFR Monoclonal Antibodies in the Treatment of Squamous Cell Carcinoma of the Head and Neck : A View beyond Cetuximab. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-506531
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kono, Scott A.…[et al.]. EGFR Monoclonal Antibodies in the Treatment of Squamous Cell Carcinoma of the Head and Neck : A View beyond Cetuximab. Chemotherapy Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-506531
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kono, Scott A.& Haigentz, Missak& Yom, Sue S.& Saba, Nabil F.. EGFR Monoclonal Antibodies in the Treatment of Squamous Cell Carcinoma of the Head and Neck : A View beyond Cetuximab. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-506531
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506531
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)