EGFR Monoclonal Antibodies in the Treatment of Squamous Cell Carcinoma of the Head and Neck : A View beyond Cetuximab
Joint Authors
Saba, Nabil F.
Kono, Scott A.
Haigentz, Missak
Yom, Sue S.
Source
Chemotherapy Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Squamous cell carcinoma of the head and neck (SCCHN) is a prevalent disease both in the United States and worldwide with an overall poor prognosis, in part due to limited activity of existing therapy.
Primary therapy is largely dictated by the anatomical origin of the cancer and whether distant disease is present.
Many patients with localized disease are treated with chemoradiotherapy, either in the definitive or adjuvant setting, and those with metastatic disease are treated with palliative chemotherapy.
The chemotherapy used in SCCHN can be toxic, whether given with radiation or alone.
The epidermal growth factor receptor (EGFR) is highly expressed in SCCHN and serves as a logical therapeutic target.
EGFR-directed monoclonal antibodies (MoAbs) have higher activity in SCCHN than small molecule tyrosine kinase inhibitors.
Cetuximab, a widely studied EGFR MoAb, is FDA approved in the metastatic setting, as well as with radiation for locally advanced disease.
Despite improvements in survival when cetuximab is incorporated with chemotherapy for metastatic disease, the prognosis of patients remains poor.
Novel EGFR MoAbs are being developed with the goal of improving efficacy and tolerability.
This paper will summarize the use of EGFR-directed MoAbs in treating SCCHN with a focus on novel agents being tested.
American Psychological Association (APA)
Kono, Scott A.& Haigentz, Missak& Yom, Sue S.& Saba, Nabil F.. 2012. EGFR Monoclonal Antibodies in the Treatment of Squamous Cell Carcinoma of the Head and Neck : A View beyond Cetuximab. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-506531
Modern Language Association (MLA)
Kono, Scott A.…[et al.]. EGFR Monoclonal Antibodies in the Treatment of Squamous Cell Carcinoma of the Head and Neck : A View beyond Cetuximab. Chemotherapy Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-506531
American Medical Association (AMA)
Kono, Scott A.& Haigentz, Missak& Yom, Sue S.& Saba, Nabil F.. EGFR Monoclonal Antibodies in the Treatment of Squamous Cell Carcinoma of the Head and Neck : A View beyond Cetuximab. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-506531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506531