Improved Outcome of Biliary Atresia with Postoperative High-Dose Steroid

الملخص EN

Objective.

The dosage, duration, and the benefits of high-dose steroid treatment and outcome in biliary atresia (BA) remain controversial.

In this study, we evaluated the impact of high-dose steroid therapy on the outcome of BA after the Kasai procedure.

Methods.

Intravenous prednisolone administration was started 1 week after surgery, followed by 8 to 12 weeks of oral prednisolone.

Total bilirubin (TB) levels (3, 6, and 12 months after surgery), early onset of cholangitis, and two-year native liver survival were evaluated.

Results.

53.4%, 56.9%, and 58.1% of the patients in the high-dose steroid group were jaundice-free 3, 6, and 12 months after surgery, respectively; these values were significantly higher than the 38.7%, 39.4%, and 43.3% of the low-dose steroid group.

One year after surgery, the incidence of cholangitis in the high-dose group (32.0%) was lower than that in the low-dose group (48.0%).

Infants with native liver in the high-dose group had a better two-year survival compared to those in the low-dose steroid group (53.7% versus 42.6%).

Conclusions.

The high-dose steroid protocol can reduce the incidence of cholangitis, increase the jaundice-free rate, and improve two-year survival with native liver after the Kasai operation.