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Improved Outcome of Biliary Atresia with Postoperative High-Dose Steroid
Joint Authors
Xiao, Xian-min
Chen, Gong
Zheng, Shan
Song, Zai
Dong, Rui
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
The dosage, duration, and the benefits of high-dose steroid treatment and outcome in biliary atresia (BA) remain controversial.
In this study, we evaluated the impact of high-dose steroid therapy on the outcome of BA after the Kasai procedure.
Methods.
Intravenous prednisolone administration was started 1 week after surgery, followed by 8 to 12 weeks of oral prednisolone.
Total bilirubin (TB) levels (3, 6, and 12 months after surgery), early onset of cholangitis, and two-year native liver survival were evaluated.
Results.
53.4%, 56.9%, and 58.1% of the patients in the high-dose steroid group were jaundice-free 3, 6, and 12 months after surgery, respectively; these values were significantly higher than the 38.7%, 39.4%, and 43.3% of the low-dose steroid group.
One year after surgery, the incidence of cholangitis in the high-dose group (32.0%) was lower than that in the low-dose group (48.0%).
Infants with native liver in the high-dose group had a better two-year survival compared to those in the low-dose steroid group (53.7% versus 42.6%).
Conclusions.
The high-dose steroid protocol can reduce the incidence of cholangitis, increase the jaundice-free rate, and improve two-year survival with native liver after the Kasai operation.
American Psychological Association (APA)
Dong, Rui& Song, Zai& Chen, Gong& Zheng, Shan& Xiao, Xian-min. 2013. Improved Outcome of Biliary Atresia with Postoperative High-Dose Steroid. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-506634
Modern Language Association (MLA)
Dong, Rui…[et al.]. Improved Outcome of Biliary Atresia with Postoperative High-Dose Steroid. Gastroenterology Research and Practice No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-506634
American Medical Association (AMA)
Dong, Rui& Song, Zai& Chen, Gong& Zheng, Shan& Xiao, Xian-min. Improved Outcome of Biliary Atresia with Postoperative High-Dose Steroid. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-506634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506634