Synthesis and Biological Evaluation of Achiral Indole-Substituted Titanocene Dichloride Derivatives

المؤلفون المشاركون

Tacke, Matthias
Lally, Grainne
Hackenberg, Frauke
Deally, Anthony

المصدر

International Journal of Medicinal Chemistry

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-06-12

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

الكيمياء
علم الصيدلة

الملخص EN

Six new titanocene compounds have been isolated and characterised.

These compounds were synthesised from their fulvene precursors using Super Hydride (LiBEt3H) followed by transmetallation with titanium tetrachloride to yield the corresponding titanocene dichloride derivatives.

These complexes are bis-[((1-methyl-3-diethylaminomethyl)indol-2-yl)methylcyclopentadienyl] titanium (IV) dichloride (5a), bis-[((5-methoxy-1-methyl,3-diethylaminomethyl)indol-2-yl)methylcyclopentadienyl] titanium (IV) dichloride (5b), bis-[((1-methyl,3-diethylaminomethyl)indol-4-yl)methylcyclopentadienyl] titanium (IV) dichloride (5c), bis-[((5-bromo-1-methyl)indol-3-yl)methylcyclopentadienyl] titanium (IV) dichloride (5d), bis-[((5-chloro-1-methyl)indol-3-yl)methylcyclopentadienyl] titanium (IV) dichloride (5e), and bis-[((5-fluoro-1-methyl)indol-3-yl)methylcyclopentadienyl] titanium (IV) dichloride (5f).

All six titanocenes 5a–5f were tested for their cytotoxicity through MTT-based in vitro tests on CAKI-1 cell lines using DMSO and Soluphor P as solubilising agents in order to determine their IC50 values.

Titanocenes 5a–5f were found to have IC50 values of 10 (±2), 21 (±3), 29 (±4), 140 (±6), and 450 (±10) μM when tested using DMSO.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Deally, Anthony& Hackenberg, Frauke& Lally, Grainne& Tacke, Matthias. 2012. Synthesis and Biological Evaluation of Achiral Indole-Substituted Titanocene Dichloride Derivatives. International Journal of Medicinal Chemistry،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-506967

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Deally, Anthony…[et al.]. Synthesis and Biological Evaluation of Achiral Indole-Substituted Titanocene Dichloride Derivatives. International Journal of Medicinal Chemistry No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-506967

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Deally, Anthony& Hackenberg, Frauke& Lally, Grainne& Tacke, Matthias. Synthesis and Biological Evaluation of Achiral Indole-Substituted Titanocene Dichloride Derivatives. International Journal of Medicinal Chemistry. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-506967

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-506967