Synthesis and Biological Evaluation of Achiral Indole-Substituted Titanocene Dichloride Derivatives
Joint Authors
Tacke, Matthias
Lally, Grainne
Hackenberg, Frauke
Deally, Anthony
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Six new titanocene compounds have been isolated and characterised.
These compounds were synthesised from their fulvene precursors using Super Hydride (LiBEt3H) followed by transmetallation with titanium tetrachloride to yield the corresponding titanocene dichloride derivatives.
These complexes are bis-[((1-methyl-3-diethylaminomethyl)indol-2-yl)methylcyclopentadienyl] titanium (IV) dichloride (5a), bis-[((5-methoxy-1-methyl,3-diethylaminomethyl)indol-2-yl)methylcyclopentadienyl] titanium (IV) dichloride (5b), bis-[((1-methyl,3-diethylaminomethyl)indol-4-yl)methylcyclopentadienyl] titanium (IV) dichloride (5c), bis-[((5-bromo-1-methyl)indol-3-yl)methylcyclopentadienyl] titanium (IV) dichloride (5d), bis-[((5-chloro-1-methyl)indol-3-yl)methylcyclopentadienyl] titanium (IV) dichloride (5e), and bis-[((5-fluoro-1-methyl)indol-3-yl)methylcyclopentadienyl] titanium (IV) dichloride (5f).
All six titanocenes 5a–5f were tested for their cytotoxicity through MTT-based in vitro tests on CAKI-1 cell lines using DMSO and Soluphor P as solubilising agents in order to determine their IC50 values.
Titanocenes 5a–5f were found to have IC50 values of 10 (±2), 21 (±3), 29 (±4), 140 (±6), and 450 (±10) μM when tested using DMSO.
American Psychological Association (APA)
Deally, Anthony& Hackenberg, Frauke& Lally, Grainne& Tacke, Matthias. 2012. Synthesis and Biological Evaluation of Achiral Indole-Substituted Titanocene Dichloride Derivatives. International Journal of Medicinal Chemistry،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-506967
Modern Language Association (MLA)
Deally, Anthony…[et al.]. Synthesis and Biological Evaluation of Achiral Indole-Substituted Titanocene Dichloride Derivatives. International Journal of Medicinal Chemistry No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-506967
American Medical Association (AMA)
Deally, Anthony& Hackenberg, Frauke& Lally, Grainne& Tacke, Matthias. Synthesis and Biological Evaluation of Achiral Indole-Substituted Titanocene Dichloride Derivatives. International Journal of Medicinal Chemistry. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-506967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506967