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Clinical Impact of Hypercalcemia in Kidney Transplant
المؤلفون المشاركون
Alfieri, Carlo
Messa, Piergiorgio
Cafforio, Cosimo
المصدر
International Journal of Nephrology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Hypercalcemia (HC) has been variably reported in kidney transplanted (KTx) recipients (5–15%).
Calcium levels peak around the 3rd month after KTx and thereafter slightly reduce and stabilize.
Though many factors have been claimed to induce HC after KTx, the persistence of posttransplant hyperparathyroidism (PT-HPT) of moderate-severe degree is universally considered the first causal factor.
Though not proven, there are experimental and clinical suggestions that HC can adversely affect either the graft (nephrocalcinosis) and other organs or systems (vascular calcifications, erythrocytosis, pancreatitis, etc.).
However, there is no conclusive evidence that correction of serum calcium levels might avoid the occurrence of these claimed clinical effects of HC.
The best way to reduce the occurrence of HC after KTx is to treat as best we can the secondary hyperparathyroidism (SHP) during the uraemic stages.
The indication to Parathyroidectomy (PTX), either before or after KTx, in order to prevent or to treat, respectively, HC after KTx, is still a matter of debate which has been revived by the availability of the calcimimetic cinacalcet for the treatment of PT-HPT.
However, we still need to better clarify many points as regards the potential adverse effects related to either PTX or cinacalcet use in this clinical set, and we are waiting for the results of future randomized controlled trials to achieve some more definite conclusions on this topic.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Messa, Piergiorgio& Cafforio, Cosimo& Alfieri, Carlo. 2011. Clinical Impact of Hypercalcemia in Kidney Transplant. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-507052
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Messa, Piergiorgio…[et al.]. Clinical Impact of Hypercalcemia in Kidney Transplant. International Journal of Nephrology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-507052
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Messa, Piergiorgio& Cafforio, Cosimo& Alfieri, Carlo. Clinical Impact of Hypercalcemia in Kidney Transplant. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-507052
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507052
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