Clinical Impact of Hypercalcemia in Kidney Transplant
Joint Authors
Alfieri, Carlo
Messa, Piergiorgio
Cafforio, Cosimo
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hypercalcemia (HC) has been variably reported in kidney transplanted (KTx) recipients (5–15%).
Calcium levels peak around the 3rd month after KTx and thereafter slightly reduce and stabilize.
Though many factors have been claimed to induce HC after KTx, the persistence of posttransplant hyperparathyroidism (PT-HPT) of moderate-severe degree is universally considered the first causal factor.
Though not proven, there are experimental and clinical suggestions that HC can adversely affect either the graft (nephrocalcinosis) and other organs or systems (vascular calcifications, erythrocytosis, pancreatitis, etc.).
However, there is no conclusive evidence that correction of serum calcium levels might avoid the occurrence of these claimed clinical effects of HC.
The best way to reduce the occurrence of HC after KTx is to treat as best we can the secondary hyperparathyroidism (SHP) during the uraemic stages.
The indication to Parathyroidectomy (PTX), either before or after KTx, in order to prevent or to treat, respectively, HC after KTx, is still a matter of debate which has been revived by the availability of the calcimimetic cinacalcet for the treatment of PT-HPT.
However, we still need to better clarify many points as regards the potential adverse effects related to either PTX or cinacalcet use in this clinical set, and we are waiting for the results of future randomized controlled trials to achieve some more definite conclusions on this topic.
American Psychological Association (APA)
Messa, Piergiorgio& Cafforio, Cosimo& Alfieri, Carlo. 2011. Clinical Impact of Hypercalcemia in Kidney Transplant. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-507052
Modern Language Association (MLA)
Messa, Piergiorgio…[et al.]. Clinical Impact of Hypercalcemia in Kidney Transplant. International Journal of Nephrology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-507052
American Medical Association (AMA)
Messa, Piergiorgio& Cafforio, Cosimo& Alfieri, Carlo. Clinical Impact of Hypercalcemia in Kidney Transplant. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-507052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507052