Amyloid Oligomer Neurotoxicity, Calcium Dysregulation, and Lipid Rafts
المؤلفون المشاركون
Matteucci, Andrea
Malchiodi-Albedi, Fiorella
Paradisi, Silvia
Frank, Claudio
Diociaiuti, Marco
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-08
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Amyloid proteins constitute a chemically heterogeneous group of proteins, which share some biophysical and biological characteristics, the principal of which are the high propensity to acquire an incorrect folding and the tendency to aggregate.
A number of diseases are associated with misfolding and aggregation of proteins, although only in some of them—most notably Alzheimer's disease (AD) and transmissible spongiform encephalopathies (TSEs)—a pathogenetic link with misfolded proteins is now widely recognized.
Lipid rafts (LRs) have been involved in the pathophysiology of diseases associated with protein misfolding at several levels, including aggregation of misfolded proteins, amyloidogenic processing, and neurotoxicity.
Among the pathogenic misfolded proteins, the AD-related protein amyloid β (Aβ) is by far the most studied protein, and a large body of evidence has been gathered on the role played by LRs in Aβ pathogenicity.
However, significant amount of data has also been collected for several other amyloid proteins, so that their ability to interact with LRs can be considered an additional, shared feature characterizing the amyloid protein family.
In this paper, we will review the evidence on the role of LRs in the neurotoxicity of huntingtin, α-synuclein, prion protein, and calcitonin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Malchiodi-Albedi, Fiorella& Paradisi, Silvia& Matteucci, Andrea& Frank, Claudio& Diociaiuti, Marco. 2011. Amyloid Oligomer Neurotoxicity, Calcium Dysregulation, and Lipid Rafts. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-507074
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Malchiodi-Albedi, Fiorella…[et al.]. Amyloid Oligomer Neurotoxicity, Calcium Dysregulation, and Lipid Rafts. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-507074
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Malchiodi-Albedi, Fiorella& Paradisi, Silvia& Matteucci, Andrea& Frank, Claudio& Diociaiuti, Marco. Amyloid Oligomer Neurotoxicity, Calcium Dysregulation, and Lipid Rafts. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-507074
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507074
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر