Amyloid Oligomer Neurotoxicity, Calcium Dysregulation, and Lipid Rafts
Joint Authors
Matteucci, Andrea
Malchiodi-Albedi, Fiorella
Paradisi, Silvia
Frank, Claudio
Diociaiuti, Marco
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-08
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Amyloid proteins constitute a chemically heterogeneous group of proteins, which share some biophysical and biological characteristics, the principal of which are the high propensity to acquire an incorrect folding and the tendency to aggregate.
A number of diseases are associated with misfolding and aggregation of proteins, although only in some of them—most notably Alzheimer's disease (AD) and transmissible spongiform encephalopathies (TSEs)—a pathogenetic link with misfolded proteins is now widely recognized.
Lipid rafts (LRs) have been involved in the pathophysiology of diseases associated with protein misfolding at several levels, including aggregation of misfolded proteins, amyloidogenic processing, and neurotoxicity.
Among the pathogenic misfolded proteins, the AD-related protein amyloid β (Aβ) is by far the most studied protein, and a large body of evidence has been gathered on the role played by LRs in Aβ pathogenicity.
However, significant amount of data has also been collected for several other amyloid proteins, so that their ability to interact with LRs can be considered an additional, shared feature characterizing the amyloid protein family.
In this paper, we will review the evidence on the role of LRs in the neurotoxicity of huntingtin, α-synuclein, prion protein, and calcitonin.
American Psychological Association (APA)
Malchiodi-Albedi, Fiorella& Paradisi, Silvia& Matteucci, Andrea& Frank, Claudio& Diociaiuti, Marco. 2011. Amyloid Oligomer Neurotoxicity, Calcium Dysregulation, and Lipid Rafts. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-507074
Modern Language Association (MLA)
Malchiodi-Albedi, Fiorella…[et al.]. Amyloid Oligomer Neurotoxicity, Calcium Dysregulation, and Lipid Rafts. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-507074
American Medical Association (AMA)
Malchiodi-Albedi, Fiorella& Paradisi, Silvia& Matteucci, Andrea& Frank, Claudio& Diociaiuti, Marco. Amyloid Oligomer Neurotoxicity, Calcium Dysregulation, and Lipid Rafts. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-507074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507074