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Physiologically Based Pharmacokinetic Modeling : Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development
المؤلفون المشاركون
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The concept of physiologically based pharmacokinetic (PBPK) modeling was introduced years ago, but it has not been practiced significantly.
However, interest in and implementation of this modeling technique have grown, as evidenced by the increased number of publications in this field.
This paper demonstrates briefly the methodology, applications, and limitations of PBPK modeling with special attention given to discuss the use of PBPK models in pediatric drug development and some examples described in detail.
Although PBPK models do have some limitations, the potential benefit from PBPK modeling technique is huge.
PBPK models can be applied to investigate drug pharmacokinetics under different physiological and pathological conditions or in different age groups, to support decision-making during drug discovery, to provide, perhaps most important, data that can save time and resources, especially in early drug development phases and in pediatric clinical trials, and potentially to help clinical trials become more “confirmatory” rather than “exploratory”.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khalil, Feras& Laër, Stephanie. 2011. Physiologically Based Pharmacokinetic Modeling : Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-507136
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khalil, Feras& Laër, Stephanie. Physiologically Based Pharmacokinetic Modeling : Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-507136
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khalil, Feras& Laër, Stephanie. Physiologically Based Pharmacokinetic Modeling : Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-507136
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507136
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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