Physiologically Based Pharmacokinetic Modeling : Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development
Joint Authors
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The concept of physiologically based pharmacokinetic (PBPK) modeling was introduced years ago, but it has not been practiced significantly.
However, interest in and implementation of this modeling technique have grown, as evidenced by the increased number of publications in this field.
This paper demonstrates briefly the methodology, applications, and limitations of PBPK modeling with special attention given to discuss the use of PBPK models in pediatric drug development and some examples described in detail.
Although PBPK models do have some limitations, the potential benefit from PBPK modeling technique is huge.
PBPK models can be applied to investigate drug pharmacokinetics under different physiological and pathological conditions or in different age groups, to support decision-making during drug discovery, to provide, perhaps most important, data that can save time and resources, especially in early drug development phases and in pediatric clinical trials, and potentially to help clinical trials become more “confirmatory” rather than “exploratory”.
American Psychological Association (APA)
Khalil, Feras& Laër, Stephanie. 2011. Physiologically Based Pharmacokinetic Modeling : Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-507136
Modern Language Association (MLA)
Khalil, Feras& Laër, Stephanie. Physiologically Based Pharmacokinetic Modeling : Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-507136
American Medical Association (AMA)
Khalil, Feras& Laër, Stephanie. Physiologically Based Pharmacokinetic Modeling : Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-507136
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507136