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Enzymatic Digestion and Selective Quantification of Underivatised Delta-9-Tetrahydrocannabinol and Cocaine in Human Hair Using Gas Chromatography-Mass Spectrometry
المؤلفون المشاركون
Barker, James
Petróczi, Andrea
Breidi, Salah Eddine
Naughton, Declan P.
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Gas chromatography-mass spectrometric (GC-MS) methods for drug analysis routinely employ derivatising reagents.
The aim of this paper was to develop a method for the analysis of two recreational drugs, delta-9-tetrahydrocannabinol (Δ9-THC) and cocaine in hair samples using GC-MS, without prior derivatisation, thus allowing the sample to be reanalysed in its original form.
An enzymatic digestion technique was also developed.
Ten hair samples, that were known positive for either Δ9-THC and/or cocaine, were enzymatically digested, extracted, and then analysed by GC-MS.
All samples measured contained Δ9-THC and one sample contained cocaine.
The limits of detection (LOD) and quantification (LOQ) were 0.02 ng/mg and 0.05 ng/mg, respectively, for cocaine and 0.015 ng/mg and 0.02 ng/mg, respectively, for Δ9-THC.
The wide detection window, ease of direct analysis by GC-MS, lower detection limits of underivatised samples, and the stability of drugs using this technique may offer an improved method of analysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Breidi, Salah Eddine& Barker, James& Petróczi, Andrea& Naughton, Declan P.. 2012. Enzymatic Digestion and Selective Quantification of Underivatised Delta-9-Tetrahydrocannabinol and Cocaine in Human Hair Using Gas Chromatography-Mass Spectrometry. Journal of Analytical Methods in Chemistry،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-507171
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Breidi, Salah Eddine…[et al.]. Enzymatic Digestion and Selective Quantification of Underivatised Delta-9-Tetrahydrocannabinol and Cocaine in Human Hair Using Gas Chromatography-Mass Spectrometry. Journal of Analytical Methods in Chemistry No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-507171
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Breidi, Salah Eddine& Barker, James& Petróczi, Andrea& Naughton, Declan P.. Enzymatic Digestion and Selective Quantification of Underivatised Delta-9-Tetrahydrocannabinol and Cocaine in Human Hair Using Gas Chromatography-Mass Spectrometry. Journal of Analytical Methods in Chemistry. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-507171
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507171
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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