Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis

المؤلفون المشاركون

Qazi, Basit Saleem
Qazi, Asma
Tang, Kai

المصدر

International Journal of Inflammation

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-12-22

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Interleukin-8 has long been recognized to have anti-inflammatory activity, which has been established in various models of infection, inflammation, and cancer.

Several cell types express the receptor for the cytokine IL-8 and upon its recognition produce molecules that are active both locally and systemically.

Many different types of cells, in particular monocytes, neutrophils, epithelial, fibroblast, endothelial, mesothelial, and tumor cells, secrete IL-8.

Increased expression of IL-8 and/or its receptors has been characterized in many chronic inflammatory conditions, including psoriasis, ARDS, COPD, and RA as well as many cancers, and its upregulation often correlates with disease activity.

IL-8 constitutes the CXC class of chemokines, a potent chemoattractant and activator of neutrophils and other immune cells.

It is a proangiogenic cytokine that is overexpressed in many human cancers.

Therefore, inhibiting the effects of IL-8 signaling may be a significant therapeutic intervention.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Qazi, Basit Saleem& Tang, Kai& Qazi, Asma. 2011. Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-507233

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Qazi, Basit Saleem…[et al.]. Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis. International Journal of Inflammation No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-507233

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Qazi, Basit Saleem& Tang, Kai& Qazi, Asma. Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-507233

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-507233