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Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis
Joint Authors
Qazi, Basit Saleem
Qazi, Asma
Tang, Kai
Source
International Journal of Inflammation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Interleukin-8 has long been recognized to have anti-inflammatory activity, which has been established in various models of infection, inflammation, and cancer.
Several cell types express the receptor for the cytokine IL-8 and upon its recognition produce molecules that are active both locally and systemically.
Many different types of cells, in particular monocytes, neutrophils, epithelial, fibroblast, endothelial, mesothelial, and tumor cells, secrete IL-8.
Increased expression of IL-8 and/or its receptors has been characterized in many chronic inflammatory conditions, including psoriasis, ARDS, COPD, and RA as well as many cancers, and its upregulation often correlates with disease activity.
IL-8 constitutes the CXC class of chemokines, a potent chemoattractant and activator of neutrophils and other immune cells.
It is a proangiogenic cytokine that is overexpressed in many human cancers.
Therefore, inhibiting the effects of IL-8 signaling may be a significant therapeutic intervention.
American Psychological Association (APA)
Qazi, Basit Saleem& Tang, Kai& Qazi, Asma. 2011. Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-507233
Modern Language Association (MLA)
Qazi, Basit Saleem…[et al.]. Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis. International Journal of Inflammation No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-507233
American Medical Association (AMA)
Qazi, Basit Saleem& Tang, Kai& Qazi, Asma. Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-507233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507233