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Flavonoids Identified from Korean Scutellaria baicalensis Georgi Inhibit Inflammatory Signaling by Suppressing Activation of NF-κB and MAPK in RAW 264.7 Cells
المؤلفون المشاركون
Lee, Won-Sup
Lee, Ho-Jeong
Kim, Jin-A.
Yumnam, Silvia
Shin, Sung-Chul
Kim, Gon-Sup
Park, Hyeon-Soo
Hong, Gyeong-Eun
Kim, Eun-Hee
Nagappan, Arulkumar
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Scutellaria baicalensis Georgi has been used as traditional medicine for treating inflammatory diseases, hepatitis, tumors, and diarrhea in Asia.
Hence, we investigated the anti-inflammatory effect and determined the molecular mechanism of action of flavonoids isolated from Korean S.
baicalensis G.
in lipopolysaccharide- (LPS-) stimulated RAW 264.7 macrophages.
A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed to examine cytotoxicity of the flavonoids at various concentrations of 10, 40, 70, and 100 µg/mL.
No cytotoxicity was observed in RAW 264.7 cells at these concentrations.
Furthermore, the flavonoids decreased production of inflammatory mediators such as inducible nitric oxide synthase, cyclooxygenase-2, interleukin-6, and tumor necrosis factor-alpha and inhibited phosphorylation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) in LPS-induced RAW 264.7 cells.
Moreover, to identify the differentially expressed proteins in RAW 264.7 cells of the control, LPS-treated, and flavonoid-treated groups, two-dimensional gel electrophoresis and mass spectrometry were conducted.
The identified proteins were involved in the inflammatory response and included PRKA anchor protein and heat shock protein 70 kD.
These findings suggest that the flavonoids isolated from S.
baicalensis G.
might have anti-inflammatory effects that regulate the expression of inflammatory mediators by inhibiting the NF-κB signaling pathway via the MAPK signaling pathway in RAW 264.7 cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hong, Gyeong-Eun& Kim, Jin-A.& Nagappan, Arulkumar& Yumnam, Silvia& Lee, Ho-Jeong& Kim, Eun-Hee…[et al.]. 2013. Flavonoids Identified from Korean Scutellaria baicalensis Georgi Inhibit Inflammatory Signaling by Suppressing Activation of NF-κB and MAPK in RAW 264.7 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-507457
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hong, Gyeong-Eun…[et al.]. Flavonoids Identified from Korean Scutellaria baicalensis Georgi Inhibit Inflammatory Signaling by Suppressing Activation of NF-κB and MAPK in RAW 264.7 Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-507457
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hong, Gyeong-Eun& Kim, Jin-A.& Nagappan, Arulkumar& Yumnam, Silvia& Lee, Ho-Jeong& Kim, Eun-Hee…[et al.]. Flavonoids Identified from Korean Scutellaria baicalensis Georgi Inhibit Inflammatory Signaling by Suppressing Activation of NF-κB and MAPK in RAW 264.7 Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-507457
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507457
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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