Keishibukuryogan Reduces Renal Injury in the Early Stage of Renal Failure in the Remnant Kidney Model
المؤلفون المشاركون
Shibahara, Naotoshi
Oka, Hiroshi
Goto, Hirozo
Sakai, Shinya
Shimada, Yutaka
Tashiro, Izumi
Fujimoto, Makoto
Nakagawa, Takako
Jo, Michiko
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-05-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The effects of keishibukuryogan on the early stage of progressive renal failure were examined in rats subjected to 5/6 nephrectomy.
Keishibukuryogan, one of the traditional herbal formulations, was given orally at a dose of 1% (w/w) and 3% (w/w) in chow.
Administration of keishibukuryogan was started at 1 week after 5/6 nephrectomy and was continued for 4 weeks.
At the end of the experiment, Azan staining did not reveal any severe histological changes in the kidneys of the nephrectomized rats.
On the other hand, significant increases in mRNA expressions of transforming growth factor-β1 and fibronectin related to tissue fibrosis, as examined by Reverse Transcriptase-Polymerase Chain Reaction, were observed in nephrectomized rats, and they were significantly suppressed by 3% keishibukuryogan treatment.
Against gene expressions related to macrophage infiltration, 3% keishibukuryogan treatment significantly suppressed osteopontin mRNA levels, and monocyte chemoattractant protein-1 and vascular cell adhesion molecule-1 mRNA levels showed a tendency to decrease, but without statistical significance.
It was also observed that 3% keishibukuryogan attenuated serum urea nitrogen and urinary protein excretion levels.
From these results, it was suggested that keishibukuryogan exerts beneficial effects that result in slowing the progression of chronic renal failure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nakagawa, Takako& Tashiro, Izumi& Fujimoto, Makoto& Jo, Michiko& Sakai, Shinya& Oka, Hiroshi…[et al.]. 2011. Keishibukuryogan Reduces Renal Injury in the Early Stage of Renal Failure in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-507663
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nakagawa, Takako…[et al.]. Keishibukuryogan Reduces Renal Injury in the Early Stage of Renal Failure in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-507663
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nakagawa, Takako& Tashiro, Izumi& Fujimoto, Makoto& Jo, Michiko& Sakai, Shinya& Oka, Hiroshi…[et al.]. Keishibukuryogan Reduces Renal Injury in the Early Stage of Renal Failure in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-507663
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507663
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر