![](/images/graphics-bg.png)
Keishibukuryogan Reduces Renal Injury in the Early Stage of Renal Failure in the Remnant Kidney Model
Joint Authors
Shibahara, Naotoshi
Oka, Hiroshi
Goto, Hirozo
Sakai, Shinya
Shimada, Yutaka
Tashiro, Izumi
Fujimoto, Makoto
Nakagawa, Takako
Jo, Michiko
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The effects of keishibukuryogan on the early stage of progressive renal failure were examined in rats subjected to 5/6 nephrectomy.
Keishibukuryogan, one of the traditional herbal formulations, was given orally at a dose of 1% (w/w) and 3% (w/w) in chow.
Administration of keishibukuryogan was started at 1 week after 5/6 nephrectomy and was continued for 4 weeks.
At the end of the experiment, Azan staining did not reveal any severe histological changes in the kidneys of the nephrectomized rats.
On the other hand, significant increases in mRNA expressions of transforming growth factor-β1 and fibronectin related to tissue fibrosis, as examined by Reverse Transcriptase-Polymerase Chain Reaction, were observed in nephrectomized rats, and they were significantly suppressed by 3% keishibukuryogan treatment.
Against gene expressions related to macrophage infiltration, 3% keishibukuryogan treatment significantly suppressed osteopontin mRNA levels, and monocyte chemoattractant protein-1 and vascular cell adhesion molecule-1 mRNA levels showed a tendency to decrease, but without statistical significance.
It was also observed that 3% keishibukuryogan attenuated serum urea nitrogen and urinary protein excretion levels.
From these results, it was suggested that keishibukuryogan exerts beneficial effects that result in slowing the progression of chronic renal failure.
American Psychological Association (APA)
Nakagawa, Takako& Tashiro, Izumi& Fujimoto, Makoto& Jo, Michiko& Sakai, Shinya& Oka, Hiroshi…[et al.]. 2011. Keishibukuryogan Reduces Renal Injury in the Early Stage of Renal Failure in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-507663
Modern Language Association (MLA)
Nakagawa, Takako…[et al.]. Keishibukuryogan Reduces Renal Injury in the Early Stage of Renal Failure in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-507663
American Medical Association (AMA)
Nakagawa, Takako& Tashiro, Izumi& Fujimoto, Makoto& Jo, Michiko& Sakai, Shinya& Oka, Hiroshi…[et al.]. Keishibukuryogan Reduces Renal Injury in the Early Stage of Renal Failure in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-507663
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507663