Dried Ginger (Zingiber officinalis)‎ Inhibits Inflammation in a Lipopolysaccharide-Induced Mouse Model

الملخص EN

Objectives.

Ginger rhizomes have a long history of human use, especially with regards to their anti-inflammatory properties.

However, the mechanisms by which ginger acts on lipopolysaccharide-(LPS-)induced inflammation have not yet been identified.

We investigated the anti-inflammatory effects of dried Zingiber officinalis (DZO) on LPS-induced hepatic injury.

Methods.

ICR mice were given a DZO water extract (100, 1000 mg/kg) orally for three consecutive days.

On the third day, they were administered by LPS intraperitoneally.

To investigate the anti-inflammatory effects of DZO, histological, cytokine expression, and protein factor analyses were performed.

Results.

Oral administration of DZO significantly reduced pathological changes in the liver and proinflammatory cytokines including interferon-(IFN-)γ and interleukin-(IL-)6 in the serum.

In addition, DZO inhibited LPS-induced NF-κB activation by preventing degradation of the IκB-α, as well as the phosphorylation of ERK1/2, SAPK/JNK, and p38 MAPKs.

These were associated with a decrease in the expression of inducible nitric oxide synthase (iNOS) and cyclooxyenase-2 (COX-2).

Conclusions.

Our data provide evidence for the hepatoprotective mechanisms of DZO as an anti-inflammatory effect.

Furthermore, use of DZO to treat could provide therapeutic benefits in clinical settings.