Dried Ginger (Zingiber officinalis) Inhibits Inflammation in a Lipopolysaccharide-Induced Mouse Model
Joint Authors
Kim, Mi Hye
Yang, Woong Mo
Choi, You Yeon
Kim, Sung-Hoon
Hong, Jongki
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
Ginger rhizomes have a long history of human use, especially with regards to their anti-inflammatory properties.
However, the mechanisms by which ginger acts on lipopolysaccharide-(LPS-)induced inflammation have not yet been identified.
We investigated the anti-inflammatory effects of dried Zingiber officinalis (DZO) on LPS-induced hepatic injury.
Methods.
ICR mice were given a DZO water extract (100, 1000 mg/kg) orally for three consecutive days.
On the third day, they were administered by LPS intraperitoneally.
To investigate the anti-inflammatory effects of DZO, histological, cytokine expression, and protein factor analyses were performed.
Results.
Oral administration of DZO significantly reduced pathological changes in the liver and proinflammatory cytokines including interferon-(IFN-)γ and interleukin-(IL-)6 in the serum.
In addition, DZO inhibited LPS-induced NF-κB activation by preventing degradation of the IκB-α, as well as the phosphorylation of ERK1/2, SAPK/JNK, and p38 MAPKs.
These were associated with a decrease in the expression of inducible nitric oxide synthase (iNOS) and cyclooxyenase-2 (COX-2).
Conclusions.
Our data provide evidence for the hepatoprotective mechanisms of DZO as an anti-inflammatory effect.
Furthermore, use of DZO to treat could provide therapeutic benefits in clinical settings.
American Psychological Association (APA)
Choi, You Yeon& Kim, Mi Hye& Hong, Jongki& Kim, Sung-Hoon& Yang, Woong Mo. 2013. Dried Ginger (Zingiber officinalis) Inhibits Inflammation in a Lipopolysaccharide-Induced Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-507682
Modern Language Association (MLA)
Choi, You Yeon…[et al.]. Dried Ginger (Zingiber officinalis) Inhibits Inflammation in a Lipopolysaccharide-Induced Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-507682
American Medical Association (AMA)
Choi, You Yeon& Kim, Mi Hye& Hong, Jongki& Kim, Sung-Hoon& Yang, Woong Mo. Dried Ginger (Zingiber officinalis) Inhibits Inflammation in a Lipopolysaccharide-Induced Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-507682
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507682