Synthesis and Bioevaluation of Novel Imatinib Base Derivatives via 1,1′-Carbonyldiimidazole Catalyst

الملخص EN

A series of eleven compounds were synthesized from 6-methyl-N′-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,3-diamine with various substituted carboxylic acid under solvent-free conditions using 1,1′-carbonyldiimidazole (CDI) as a catalyst.

The yields of compounds are more than 72%.

All the compounds were characterized by physical, spectroscopic, and elemental analysis.

Compound 8b exhibited good inhibition towards antimicrobial activity compared to the other compounds.