Associations of Common Variants at APLN and Hypertension in Chinese Subjects with and without Diabetes
المؤلفون المشاركون
Jia, Weiping
Wang, Congrong
Yu, Weihui
Lu, Jingyi
Hu, Cheng
Tang, Shanshan
Bao, Yu-Qian
Jiang, Feng
Xiang, Kunsan
Zhang, Rong
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-17
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Apelin, the endogenous ligand for the APJ receptor, has a potent hypotensive effect via a nitric oxide-dependent mechanism in vivo.
The aim of the study was to investigate the association between the common variants of apelin gene (APLN) and hypertension, which was reported recently in a Chinese Han population with and without diabetes.
Methods.
Three single nucleotide polymorphisms (SNPs) on APLN were genotyped in 3156 diabetic patients and 3736 nondiabetic individuals.
For non-diabetic subjects, 1779 were enrolled in stage 1 and 1757 were recruited for validation.
A meta-analysis combining the two stages was carried out to obtain the overall effect.
Results.
In diabetic patients, no significant associations of the three SNPs with hypertension were observed.
In contrast, we found that rs2235306 was associated with hypertension in non-diabetic males after adjusting for covariates (OR=1.19, P=0.039) while rs2235307 and rs3115759 displayed no evidence of association in both genders.
One haplotype, C-C-A, also showed an association with hypertension (OR=1.47, P=0.032) only in men.
However, analysis in stage 2 and meta-analysis did not support these findings.
Conclusions.
We conclude that common variants on APLN are not associated with the prevalence of hypertension in the Chinese.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Rong& Lu, Jingyi& Hu, Cheng& Wang, Congrong& Yu, Weihui& Jiang, Feng…[et al.]. 2012. Associations of Common Variants at APLN and Hypertension in Chinese Subjects with and without Diabetes. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-507962
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Rong…[et al.]. Associations of Common Variants at APLN and Hypertension in Chinese Subjects with and without Diabetes. Experimental Diabetes Research No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-507962
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Rong& Lu, Jingyi& Hu, Cheng& Wang, Congrong& Yu, Weihui& Jiang, Feng…[et al.]. Associations of Common Variants at APLN and Hypertension in Chinese Subjects with and without Diabetes. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-507962
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507962
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر