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Associations of Common Variants at APLN and Hypertension in Chinese Subjects with and without Diabetes
Joint Authors
Jia, Weiping
Wang, Congrong
Yu, Weihui
Lu, Jingyi
Hu, Cheng
Tang, Shanshan
Bao, Yu-Qian
Jiang, Feng
Xiang, Kunsan
Zhang, Rong
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Apelin, the endogenous ligand for the APJ receptor, has a potent hypotensive effect via a nitric oxide-dependent mechanism in vivo.
The aim of the study was to investigate the association between the common variants of apelin gene (APLN) and hypertension, which was reported recently in a Chinese Han population with and without diabetes.
Methods.
Three single nucleotide polymorphisms (SNPs) on APLN were genotyped in 3156 diabetic patients and 3736 nondiabetic individuals.
For non-diabetic subjects, 1779 were enrolled in stage 1 and 1757 were recruited for validation.
A meta-analysis combining the two stages was carried out to obtain the overall effect.
Results.
In diabetic patients, no significant associations of the three SNPs with hypertension were observed.
In contrast, we found that rs2235306 was associated with hypertension in non-diabetic males after adjusting for covariates (OR=1.19, P=0.039) while rs2235307 and rs3115759 displayed no evidence of association in both genders.
One haplotype, C-C-A, also showed an association with hypertension (OR=1.47, P=0.032) only in men.
However, analysis in stage 2 and meta-analysis did not support these findings.
Conclusions.
We conclude that common variants on APLN are not associated with the prevalence of hypertension in the Chinese.
American Psychological Association (APA)
Zhang, Rong& Lu, Jingyi& Hu, Cheng& Wang, Congrong& Yu, Weihui& Jiang, Feng…[et al.]. 2012. Associations of Common Variants at APLN and Hypertension in Chinese Subjects with and without Diabetes. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-507962
Modern Language Association (MLA)
Zhang, Rong…[et al.]. Associations of Common Variants at APLN and Hypertension in Chinese Subjects with and without Diabetes. Experimental Diabetes Research No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-507962
American Medical Association (AMA)
Zhang, Rong& Lu, Jingyi& Hu, Cheng& Wang, Congrong& Yu, Weihui& Jiang, Feng…[et al.]. Associations of Common Variants at APLN and Hypertension in Chinese Subjects with and without Diabetes. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-507962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507962