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Citrus junos Tanaka Peel Extract Exerts Antidiabetic Effects via AMPK and PPAR-γ both In Vitro and In Vivo in Mice Fed a High-Fat Diet
المؤلفون المشاركون
Kim, Myung-Sunny
Hur, Haeng Jeon
Sung, Mi Jeong
Kwon, Dae Young
Kim, Min Jung
Yang, Hye Jeong
Kim, Hyun Jin
Park, Jae Ho
Hwang, Jin-Taek
Kim, Sung Hee
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The antidiabetic effect of the Citrus junos Tanaka (also known as yuja or yuzu) was examined.
Ethanol extract of yuja peel (YPEE) significantly stimulated 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG) uptake in C2C12 myotubes.
However, ethanol extract of yuja pulp (YpEE) and water extract of yuja peel (YPWE) or pulp (YpWE) did not stimulate glucose uptake.
In addition, peroxisome proliferator-activated receptor gamma (PPAR-γ) and AMP-activated protein kinase (AMPK) activities were increased by YPEE in a dose-dependent manner.
Pretreatment of AMPK inhibitor decreased the glucose uptake stimulated by YPEE in C2C12 myotubes.
We confirmed the anti-diabetic effect of YPEE in mice fed a high fat-diet (HFD).
Compared with control mice on a normal diet (ND), these mice showed increased body weight, liver fat, insulin resistance, triacylglycerol (TG), and total cholesterol content.
Addition of 5% YPEE significantly reduced the weight gain and rise in liver fat content, serum triacylglycerol (TG), total cholesterol, and insulin resistance found in mice fed a high-fat diet (HFD).
Moreover, YPEE reduced the secretion of HFD-induced adipocytokines such as leptin and resistin.
YPEE also resulted in increased phosphorylation of AMPK in muscle tissues.
These results suggest that ethanol extract of yuja peel exerts anti-diabetic effects via AMPK and PPAR-γ in both cell culture and mouse models.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Sung Hee& Hur, Haeng Jeon& Yang, Hye Jeong& Kim, Hyun Jin& Kim, Min Jung& Park, Jae Ho…[et al.]. 2013. Citrus junos Tanaka Peel Extract Exerts Antidiabetic Effects via AMPK and PPAR-γ both In Vitro and In Vivo in Mice Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508285
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Sung Hee…[et al.]. Citrus junos Tanaka Peel Extract Exerts Antidiabetic Effects via AMPK and PPAR-γ both In Vitro and In Vivo in Mice Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-508285
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Sung Hee& Hur, Haeng Jeon& Yang, Hye Jeong& Kim, Hyun Jin& Kim, Min Jung& Park, Jae Ho…[et al.]. Citrus junos Tanaka Peel Extract Exerts Antidiabetic Effects via AMPK and PPAR-γ both In Vitro and In Vivo in Mice Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508285
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508285
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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