Citrus junos Tanaka Peel Extract Exerts Antidiabetic Effects via AMPK and PPAR-γ both In Vitro and In Vivo in Mice Fed a High-Fat Diet
Joint Authors
Kim, Myung-Sunny
Hur, Haeng Jeon
Sung, Mi Jeong
Kwon, Dae Young
Kim, Min Jung
Yang, Hye Jeong
Kim, Hyun Jin
Park, Jae Ho
Hwang, Jin-Taek
Kim, Sung Hee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The antidiabetic effect of the Citrus junos Tanaka (also known as yuja or yuzu) was examined.
Ethanol extract of yuja peel (YPEE) significantly stimulated 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG) uptake in C2C12 myotubes.
However, ethanol extract of yuja pulp (YpEE) and water extract of yuja peel (YPWE) or pulp (YpWE) did not stimulate glucose uptake.
In addition, peroxisome proliferator-activated receptor gamma (PPAR-γ) and AMP-activated protein kinase (AMPK) activities were increased by YPEE in a dose-dependent manner.
Pretreatment of AMPK inhibitor decreased the glucose uptake stimulated by YPEE in C2C12 myotubes.
We confirmed the anti-diabetic effect of YPEE in mice fed a high fat-diet (HFD).
Compared with control mice on a normal diet (ND), these mice showed increased body weight, liver fat, insulin resistance, triacylglycerol (TG), and total cholesterol content.
Addition of 5% YPEE significantly reduced the weight gain and rise in liver fat content, serum triacylglycerol (TG), total cholesterol, and insulin resistance found in mice fed a high-fat diet (HFD).
Moreover, YPEE reduced the secretion of HFD-induced adipocytokines such as leptin and resistin.
YPEE also resulted in increased phosphorylation of AMPK in muscle tissues.
These results suggest that ethanol extract of yuja peel exerts anti-diabetic effects via AMPK and PPAR-γ in both cell culture and mouse models.
American Psychological Association (APA)
Kim, Sung Hee& Hur, Haeng Jeon& Yang, Hye Jeong& Kim, Hyun Jin& Kim, Min Jung& Park, Jae Ho…[et al.]. 2013. Citrus junos Tanaka Peel Extract Exerts Antidiabetic Effects via AMPK and PPAR-γ both In Vitro and In Vivo in Mice Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508285
Modern Language Association (MLA)
Kim, Sung Hee…[et al.]. Citrus junos Tanaka Peel Extract Exerts Antidiabetic Effects via AMPK and PPAR-γ both In Vitro and In Vivo in Mice Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-508285
American Medical Association (AMA)
Kim, Sung Hee& Hur, Haeng Jeon& Yang, Hye Jeong& Kim, Hyun Jin& Kim, Min Jung& Park, Jae Ho…[et al.]. Citrus junos Tanaka Peel Extract Exerts Antidiabetic Effects via AMPK and PPAR-γ both In Vitro and In Vivo in Mice Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508285